Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3[3]. Zinc porphyrins are always five- or six-coordinate. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. They are for reference only. Zhonghua Er Ke Za Zhi. Products are for research use only. Please fill out this form to request the QC report. [1][4], ZnPP has been investigated for cancer therapies. As the situation with COVID-19 continues to unfold in every community, MedChemExpress is responding to the uncertainty caused by this outbreak thoughtfully and cautiously. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell deathMin-Young Kwon, et al. [15] ZnPP have been injected in a number of trials on solid tumors, but can be utilized more broadly when effectively delivered to cancer cells and not healthy cells. Zinc protoporphyrin IX. Zinc Protoporphyrin has anti-cancer activity. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 PathwayXinnong Liu, et al. Our Zinc protoporphyrin IX is confirmed by NMR. [14] The inhibition of heme oxygenase leads to an increase of reactive oxidative species in the cell which sensitizes the cells to chemotherapeutic agents. Zinc protoporphyrin (ZPP) refers to coordination complexes of zinc and protoporphyrin IX. Heme oxygenase and guanylyl cyclase inhibitor CAS# 15442-64-5. [13] ZnPP suppression of heme oxygenase reduces cell viability of cancer cells and increases cytotoxicity in cancer cells. Int J Cancer. Mwangi MN, et al. ZnPP can induce lethal. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in miceDominika Nowis, et al. A ZPP level can be. q Zinc protoporphyrin, in RBC Material: 3 ml EDTA blood TAT: 7-10 days* Method: HPLC Units: μg/g Hb. Zinc protoporphyrin in blood After 1 month exposure 2 50 pg/100 ml erythrocytes or lOOpg/IOOmI blood B. Protoporphyrine zinc. 2018 Apr 26;2018:7161592. If you have published this work, please enter the PubMed ID. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan preschool children: a community-based. Mwangi MN, et al. The fluorescent properties of ZPP in intact red cells allows the ZPP/heme molar ratio to be measured quickly, at low cost, and in a small sample volume.[6]. Sorry, but the email address you supplied was invalid. Zinc protoporphyrin (ZPP) is used to monitor chronic exposure to lead in adults. Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth. Human Endogenous Metabolite Compound Library, Anti-Cardiovascular Disease Compound Library. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. Mar Drugs. Zinc protoporphyrin (ZPP) is used to monitor chronic exposure to lead in adults. 2008 Jul 11;8:197. [1]. Explains how the zinc protoporphyrin (ZPP) test is used, when a ZPP test is requested, and what the results of a ZPP test might mean. Definition. [10] A targeted delivery system is needed to fully exploit the uses of ZnPP as a therapeutic agent and heme oxygenase inhibitor due to the potential side effects of free ZnPP on healthy tissue. CID 4971 (Protoporphyrin IX). Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Chitin is a large, structural polysaccharide found in the cell walls of fungi, the exoskeletons of insects, and certain hard structures in fish and invertebrates. PMID: 18620555. "Zinc protoporphyrin: A metabolite with a mission", "The interpretation of zinc protoporphyrin changes in lead intoxication: a case report and review of the literature", http://beaunet.beaumont.edu/portal/pls/portal/lab.lab_pkg.lab_test_info_content?xid=862, https://en.wikipedia.org/w/index.php?title=Zinc_protoporphyrin&oldid=1051887323, Articles with unsourced statements from November 2009, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 26 October 2021, at 04:35. -20°C, sealed storage, away from moisture, *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture), DMSO : 50 mg/mL (79.87 mM; Need ultrasonic), Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline, Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution, Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline), Solubility: 2.5 mg/mL (3.99 mM); Suspended solution; Need ultrasonic. Kongpetch, S., Kukongviriyapan, V., Prawan, A., Senggunprai, L., Kukongviriyapan, U., & Buranrat, B. Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL miceKaeko Hirai, et al. Oncotarget. Les porphyrines sont des pigments, dérivés tétra Les protoporphyrines érythrocytaires sont libres ou liées au zinc (protoporphyrine zinc ou PPZ) sous. Zinc protoporphyrin (ZPP) refers to coordination complexes of zinc and protoporphyrin IX. Buy Zinc Protoporphyrin (ZnPP) from AbMole BioScience. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. [10] ZnPP did not show any reduce inhibitory potential on heme oxygenase when loaded into nanoparticles. Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. We do not sell to patients. Not for human use. Life Sci. [10] Reducing the anti-oxidant capability of healthy cells can reduce effects that would have been favorable. PMID: 18339274. Please refer to the solubility information to select the appropriate solvent. [8], The early literature is sometimes confusing, and results are hard to compare without detailed examination of the measurement methods and the conversion factors used to report the results. It is a red-purple solid that is soluble in water. The virtue of elevated ZPP testing as a screen is that all of these conditions can be considered worth discovering. Planar zinc(II) complexes are unknown. 2008 Jul 11;8:197. ZnPP is finding a new use as a drug in combined cancer therapies. BMC Med. Animal A (mg/kg) = Animal B (mg/kg) multiplied by. 2014 Nov 26;12:229. [10] [11][12], ZnPP is a competitive inhibitor of heme oxygenase. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. 2008 Jul 11;8:197. Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stressDongdong Li, et al. cells: The potential involvement of lysosome-mediated degradation. [13] ZnPP works in combination with anticancer drugs to increase cytotoxicity. Zinc Protoporphyrin has anti-cancer activity[3]. zinc protoporphyrin CAS 15278-20-3 WIKI information includes physical and chemical properties, USES, security data, NMR spectroscopy, computational chemical data and more. Thank you for being a loyal MedChemExpress customer, we are here to assist you as needed. [10] The specific inhibition of heme oxygenase using nanoparticles with encapsulated ZnPP reduces side effects and is likely the future method of administering ZnPP treatment.[10]. [10] Similarly ZnPP loaded into nanoparticles has a higher cytotoxicity than free ZnPP after two days due to a more favorable release rate as well as better biodistribution and internalization. All Rights Reserved. Component Compounds. Crucial role of heme oxygenase-1 on the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents. Nowis D, et al. Rouhani, H., Sepehri, N., Montazeri, H., Khoshayand, M. R., Ghahremani, M. H., Ostad, S. N., Dinarvand, R. Zinc protoporphyrin polymeric. Probenecid sodium is water-soluble, it can reduce the amount of β-lactam antibiotics in the compound, thereby effectively reducing bacterial resistance caused by ultra-high doses of antibiotics. [14] The combination of these two therapies is highly effective in treating cancer in experiments thus far, and is a possible new method for overcoming drug resistance. [10] However ZnPP have been encapsulated in nanoparticles with specialized coating for drug delivery inside the body. Park C, et al. PNPG (4-Nitrophenyl-β-D- glucopyranoside) is a chromogenic β-D-glucosidase substrate, producing a yellow solution upon cleavage. Wang, S., Hannafon, B. N., Lind, S. E., & Ding, W. Zinc protoporphyrin suppresses beta]-catenin protein expression in human cancer Zinc protoporphyrin. Your information is safe with us. [2][3] * Required Fields. Submission failed, please try again later. Related terms: Iron Deficiency. LNV3FKZ7GR. * Please select Quantity before adding items. Because the axial ligands are labile, these complexes are often depicted with planar structures. Yin, H., Fang, J., Liao, L., Maeda, H., & Su, Q. Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity. ; 12.5, 50 mg/kg for p.o. PMID: 29854090. BMC Cancer. [9] Reports may refer to free erythrocyte protoporphyrin (FEP) or erythrocyte protoporphyrin (EP or EPP). Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. [4][1], Zinc protoporphyrin levels can be elevated as the result of a number of conditions, for instance:[2]. J Pediatr Gastroenterol Nutr. The complex and related species are found in red blood cells when heme production is inhibited by lead and/or by lack of iron. [1], Measurement of zinc protoporphyrin in red cells has been used for screening for lead poisoning. Send Us Your Feedback. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes.
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